Pregnancy; severe disturbances of liver function; a history of idiopathic jaundice and severe pruritus of pregnancy; Dubin-Johnson syndrome; Rotor syndrome; a history of or existing hepatic tumours; a history of or existing thromboembolic processes in arteries or veins and states which predispose to such diseases (eg, disturbances of the clotting system with a tendency towards thrombosis, certain heart diseases); sickle-cell anaemia; existing or treated carcinoma of the breast or endometrium; severe diabetes with vascular changes; disturbances of lipometabolism; a history of herpes of pregnancy; otosclerosis with deterioration during pregnancy.
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